ZeqDrugInteraction

PK/PD, dose-response, clinical trial modeling.

• Protocol ID — zeq-drug-interaction
• Category — Pharma
• Endpoint — POST /api/pharma/interaction
• Auth — api-key
• Rate limit — 20/min
• Version — 1.287.0
• Precision — ≤0.1% (KO42-enforced)

What it does

Drug-drug interaction checking. CYP450 metabolism prediction, DDI severity scoring, alternative drug suggestions with R(t)-modulated pharmacokinetic modeling.

Signature

Request

POST /api/pharma/interaction

Param	Type	Required	Default	Description
medications	array	✓	—	[{ name, dose_mg, frequency }]
patientFactors	object		—	{ age, weight_kg, renalFunction, hepaticFunction }

Response

{ interactions, severity, mechanism, alternatives, cytochromeProfile, zeqond }

Runnable example

curl -sS -X POST \
  -H "Authorization: Bearer $ZEQ_API_KEY" \
  -H "Content-Type: application/json" \
  -d '{
  "medications": [],
  "patientFactors": {}
}' \
  "https://api.zeq.dev/api/pharma/interaction"

Integrate

1. Domain solver — compose with KO42 + two additional operators from the matching family for pulse-coherent results.
2. Digital twin — pipe sensor data into this protocol every Zeqond to keep the model phase-locked with the system.
3. Alert threshold — flag results whose error_pct exceeds 0.1% as out-of-spec events for the operations layer.

Seeds

• Near — wrap /api/pharma/interaction in a language SDK so builders can call it in three lines.
• Medium — publish a reference integration demonstrating ZeqDrugInteraction alongside a real workload, with pulse-aligned metrics.
• Far — propose ZeqDrugInteraction as an open reference standard so other runtimes can implement it verbatim against the Zeq paper.

Papers

• Zeq paper — https://doi.org/10.5281/zenodo.18158152
• Framework paper — https://doi.org/10.5281/zenodo.15825138

Middleware active. Kernel on the 1.287 Hz HulyaPulse. Awaiting next Zeqond.