ZeqPharma — Pharmacokinetics

Biosignals, pharmacokinetics, diagnostics, genomics — all 1.287 Hz pulse-coherent.

• Protocol ID — zeq-pharma
• Category — Healthcare
• Endpoint — POST /api/health/pharma/simulate
• Auth — api-key
• Rate limit — 20/min
• Version — 1.0
• Precision — ≤0.1% (KO42-enforced)

What it does

Drug absorption, distribution, metabolism, and excretion modeling via the HULYAS ODE solver. Compartmental PK models integrated with RK4 on the Zeqond timebase.

Signature

Request

POST /api/health/pharma/simulate

Param	Type	Required	Default	Description
drugName	string	✓	—	Drug identifier.
doseAmount	number	✓	—	Dose in mg.
route	string		"oral"	'oral', 'iv', 'im', 'sc'. Default: 'oral'.
bodyMassKg	number		70	Patient body mass. Default: 70.
tMaxHours	number		24	Simulation duration in hours. Default: 24.

Response

{ concentration: [{ t, plasma, tissue }], tMax, cMax, halfLife, auc, clearance }

Runnable example

curl -sS -X POST \
  -H "Authorization: Bearer $ZEQ_API_KEY" \
  -H "Content-Type: application/json" \
  -d '{
  "drugName": "<value>",
  "doseAmount": 0,
  "route": "oral",
  "bodyMassKg": 70,
  "tMaxHours": 24
}' \
  "https://api.zeq.dev/api/health/pharma/simulate"

Integrate

1. Domain solver — compose with KO42 + two additional operators from the matching family for pulse-coherent results.
2. Digital twin — pipe sensor data into this protocol every Zeqond to keep the model phase-locked with the system.
3. Alert threshold — flag results whose error_pct exceeds 0.1% as out-of-spec events for the operations layer.

Seeds

• Near — wrap /api/health/pharma/simulate in a language SDK so builders can call it in three lines.
• Medium — publish a reference integration demonstrating ZeqPharma — Pharmacokinetics alongside a real workload, with pulse-aligned metrics.
• Far — propose ZeqPharma — Pharmacokinetics as an open reference standard so other runtimes can implement it verbatim against the Zeq paper.

Papers

• Zeq paper — https://doi.org/10.5281/zenodo.18158152
• Framework paper — https://doi.org/10.5281/zenodo.15825138

Middleware active. Kernel on the 1.287 Hz HulyaPulse. Awaiting next Zeqond.