ZeqPharmacovigilance

PK/PD, dose-response, clinical trial modeling.

• Protocol ID — zeq-pharmacovigilance
• Category — Pharma
• Endpoint — POST /api/pharma/vigilance
• Auth — api-key
• Rate limit — 10/min
• Version — 1.287.0
• Precision — ≤0.1% (KO42-enforced)

What it does

Adverse event signal detection. Disproportionality analysis (PRR/ROR), Bayesian signal detection, causality assessment with Zeqond-timestamped reporting.

Signature

Request

POST /api/pharma/vigilance

Param	Type	Required	Default	Description
reports	array	✓	—	[{ drug, event, outcome, time }]
method	string		"prr"	'prr', 'ror', 'bcpnn', 'gps'.

Response

{ signals, prr, ror, confidenceInterval, causalityScore, zeqond }

Runnable example

curl -sS -X POST \
  -H "Authorization: Bearer $ZEQ_API_KEY" \
  -H "Content-Type: application/json" \
  -d '{
  "reports": [],
  "method": "prr"
}' \
  "https://api.zeq.dev/api/pharma/vigilance"

Integrate

1. Domain solver — compose with KO42 + two additional operators from the matching family for pulse-coherent results.
2. Digital twin — pipe sensor data into this protocol every Zeqond to keep the model phase-locked with the system.
3. Alert threshold — flag results whose error_pct exceeds 0.1% as out-of-spec events for the operations layer.

Seeds

• Near — wrap /api/pharma/vigilance in a language SDK so builders can call it in three lines.
• Medium — publish a reference integration demonstrating ZeqPharmacovigilance alongside a real workload, with pulse-aligned metrics.
• Far — propose ZeqPharmacovigilance as an open reference standard so other runtimes can implement it verbatim against the Zeq paper.

Papers

• Zeq paper — https://doi.org/10.5281/zenodo.18158152
• Framework paper — https://doi.org/10.5281/zenodo.15825138

Middleware active. Kernel on the 1.287 Hz HulyaPulse. Awaiting next Zeqond.