ZeqClinicalTrial

PK/PD, dose-response, clinical trial modeling.

• Protocol ID — zeq-clinical-trial
• Category — Pharma
• Endpoint — POST /api/pharma/clinical-trial
• Auth — api-key
• Rate limit — 10/min
• Version — 1.287.0
• Precision — ≤0.1% (KO42-enforced)

What it does

Clinical trial design and power analysis. Sample size calculation, randomization, interim analysis boundaries (O'Brien-Fleming) with Zeqond enrollment timestamps.

Signature

Request

POST /api/pharma/clinical-trial

Param	Type	Required	Default	Description
endpoint	string	✓	—	'superiority', 'non-inferiority', 'equivalence'.
effectSize	number	✓	—	Expected treatment effect.
alpha	number		0.05	Significance level.
power	number		0.8	Statistical power.

Response

{ sampleSize, enrollmentTarget, interimBoundaries, trialDuration_months, zeqond }

Runnable example

curl -sS -X POST \
  -H "Authorization: Bearer $ZEQ_API_KEY" \
  -H "Content-Type: application/json" \
  -d '{
  "endpoint": "<value>",
  "effectSize": 0,
  "alpha": 0.05,
  "power": 0.8
}' \
  "https://api.zeq.dev/api/pharma/clinical-trial"

Integrate

1. Domain solver — compose with KO42 + two additional operators from the matching family for pulse-coherent results.
2. Digital twin — pipe sensor data into this protocol every Zeqond to keep the model phase-locked with the system.
3. Alert threshold — flag results whose error_pct exceeds 0.1% as out-of-spec events for the operations layer.

Seeds

• Near — wrap /api/pharma/clinical-trial in a language SDK so builders can call it in three lines.
• Medium — publish a reference integration demonstrating ZeqClinicalTrial alongside a real workload, with pulse-aligned metrics.
• Far — propose ZeqClinicalTrial as an open reference standard so other runtimes can implement it verbatim against the Zeq paper.

Papers

• Zeq paper — https://doi.org/10.5281/zenodo.18158152
• Framework paper — https://doi.org/10.5281/zenodo.15825138

Middleware active. Kernel on the 1.287 Hz HulyaPulse. Awaiting next Zeqond.